Browse Month: April 2018

PharmaTimes – in-depth news, features and insights for the pharmaceutical and healthcare sectors, online pharma.#Online

Web Exclusives

Online pharma

Stopping antibiotic resistance

This Antibiotic Awareness Week, Thomas Cueni, chair of the AMR Industry Alliance, gives some practical steps to stop one of the biggest medical threats in the world

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A new OECD gold standard for lethal injection drugs

The latest developments in a controversial area of the pharma industry

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Harnessing patient communities

Why online communities are so important to both patients and pharma

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Wish you were here?

Why UK expats in former British colonies are not missing the NHS

Magazine

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Patient Files: Ulcerative colitis

Charlotte Guinea talks about her experiences with this invisible disease

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What science really means

Five years on from Pfizer selling Discovery Park, the site s current chief executive Toby Hunter tells PharmaTimes about the plans for its future

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Age of discovery

Five years on from Pfizer selling Discovery Park, the site s current chief executive Toby Hunter tells PharmaTimes about the plans for its future

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Delivering the goods

Biotech firm Nanogenics believes that its product LipTide could solve one of the oldest problems in gene therapy delivery. Director of business development Alan Walker and director of pre-clinical development Simon Newman talk to PharmaTimes about their vision for the company and LipTide

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Compliance in finance

What does the new Criminal Finance Act mean for pharma?

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Chain reaction

How can blockchain help the pharma supply chain?

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Greater good

Richard Gardner, British Society of Gastroenterology chief executive, and Jeremy Thorpe, general manager of Tillotts Pharma UK, explain the value of joint working in IBD

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Exposing the true cost of care

Sue Thomas and Paul Midgley of Wilmington Healthcare explore how the proposed national patient data sharing scheme would change the NHS

Thought Leadership

Online pharma

Making digital engagement truly patient-centric

Digitally-augmented multi-channel engagement has proved to be a useful approach for working with patients. However, it is easy for developers to default to a patient-facing website or an app that looks good and sounds impressive, but in practice doesn t supply what patients want and need

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PharmaMar, an innovative oncology company

PharmaMar is one of the few biopharmaceutical companies to have a product on the market, another awaiting commercialisation and various more at different stages of clinical development

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Delivering true patient centric communications

The model that sees information flow linearly, from pharmaceutical companies, to healthcare professionals, or patient groups and patients, is outmoded and doesn t work well for any of the parties involved.

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Working effectively with outsourcing partners

Building better relationships based on partnership and collaboration creates more effective outcomes





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Global Healthcare Sector Analysis: Latest Market Trends and Statistics

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Global Healthcare Industry Overview

Globally, government spending contributed 55% of total healthcare expenditure in 2013, while private spending, largely funded through insurance, accounted for the remaining 45%. However, the range is wide: in Europe government spending accounted for 74% of total expenditure in 2013, whereas in South East Asia for only 38%, according to WHO.

Healthcare includes all the services, products, equipment and facilities involved in the prevention, treatment, and management of illness and the preservation of mental and physical well-being. The whole industry cover varied sectors such as the business of alternative medecine, the organization of medical facilities and medical devices, organ supplies and, more indirectly veterinarian services.

Healthcare Key Markets

The U.S. has by far the highest healthcare expenditure. Europe, too, is a major market, with the five largest countries, Germany, France, the U.K., Spain, and Italy.

Healthcare Sector Key Players

The key non-government players in the healthcare sector are the insurance companies. Healthcare providers such as hospitals, acute care centers and primary care centers are mainly small scale, though some chains are growing. The largest health insurers in the world are in the U.S.: UnitedHealth Group Inc and Anthem Inc. (former WellPoint) are the two largest insurance providers.

UnitedHealth Group provides insurance and managed care services. It offers its members access to healthcare services through a network of doctors, hospitals, clinics and medical equipment vendors. It splits its services between corporate and personal schemes, Medicare and Medicaid (state provided health programs), and military and veteran schemes. It has more than 85 million customers across the U.S. and 125 other countries, including nearly 5 million in Brazil.

Anthem (previously WellPoint) is a provider of insurance and managed care. It offers its services to national and local companies, private individuals, as part of government-sponsored Medicare and Medicaid programs, and federal employees.

Healthcare Industry Expenditure Forecast

Global expenditure on healthcare is expected to grow to $9.5 trillion in 2018 from $7.6 trillion in 2013 (at a CAGR of 4%), according to forecasts based on WHO data.

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Healthcare Sector Trends and Strategies for Growth

Four key trends are shaping the healthcare market.

Older Populations will Need More Healthcare

The size of the aging population will continue to increase over the next few decades. In 2010, individuals over the age of 65 were 8% of the total population. This is expected to increase to 16% by 2050 according to the WHO. Older people generally spend more on healthcare.

Healthcare companies should, therefore, increase their focus on age-related diseases.

Emerging Markets’ Healthcare Sectors are Expanding

Rising income levels and demand for improved healthcare in emerging economies is prompting growth of the healthcare industry in these regions. India and China, for example, have seen a rapid rise in the middle- to high- income level population and are seeing increases of healthcare expenditure per head of nearly 10% per annum, according to the World Bank.

Healthcare companies should, therefore, focus on business expansion in emerging economies.

Many Countries are Introducing Healthcare Reforms

Led by the U.S., major healthcare reforms are occurring in many countries. In 2010, the U.S. passed into law the Affordable Care Act (ACA) or Obamacare as it is known, which aims to provide unrestricted access to healthcare for all and to regulate healthcare financing. The European Union has also been focused on cost containment measures. Examples include the implementation of Arzneimittelmarkt-Neuordnungsgesetz‏ (Germany, 2011) and value-based pricing systems (U.K., 2014).

These reforms are creating huge opportunities and risks for healthcare companies; the winners will be those that understand the reforms best and react to them fastest.

More Patients will be Treated at Home

Home monitoring and telemedicine (including E-healthcare services) will assume increasing importance in the coming years. Insurance companies and governments will attempt to reduce healthcare costs by treating patients at home. The market for home healthcare devices was valued at $5.7 billion in 2013 and is expected to grow at a CAGR of 17% to reach $12.6 billion in 2018. The currently small telemedicine market is expected to grow at a CAGR of 59% over the forecast period to reach $4.5 billion in 2018.

Healthcare companies should explore opportunities in telemedicine and home monitoring.





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    If you are sick, the last thing you want to hear is the drugs you need are not available at your local drug store Canadian Pharmacy. That is why you should look us up. We are here to ensure that you get the drugs you need for you or your loved ones to get better as soon as possible. At Canadian Pharmacies we are the solution to your drug related issues. When you come to us we will ensure you get the following:

    Prescriptions drugs

    All the drugs that have been prescribed to you are available for you at our pharmacies. All you need to do is give us your prescription and your drugs will be availed to you as and when you need them. We would not like to send you away with the hope that the drugs will be delivered to you at a later hour. That is why we assure you that the service we offer you for your prescriptions is fast and efficient.

    Over the counter drugs

    We stock a wide range of over the counter drugs. Take comfort in the knowledge that our Pharmacy assistants are well trained and can understand and explain how you should take certain over the counter drugs. You also need to know that we will never let you leave our stores with drugs that may be harmful to you. We will advise as to what can be bought or not over the counter. The last thing we wish for you is for you to come back or find yourself in a bad situation out of drugs that we have sold you over the counter.

    Refills

    If you have run out of your drugs, all you need to do is let us know. You can place a call to us, email us or present yourself in person and your drugs will be refilled soon as your request is received.

    Fast and efficient service

    Our staff is highly trained to understand the prescription you present to us or the questions you may have over certain drugs. We assure you a kind, patient and understanding attitude toward you. Our customer care response is fast and efficient. We are eager to serve you within the shortest time possible and pride ourselves in friendly, fast and efficient service.

    Reminders

    Life can be busy and sometimes people forget their refills until they run out. If you are prone to forgetting when your refill is coming up, we will be happy to take down your phone number or email address and call you up when you need to do your next refill. This will ensure that you never miss to take your drugs at any time.

    We are cheap

    The costs of our drugs are pocket friendly. You need not to worry about cost as we will never rip you off. Our prices are within what is allowed by the state and what is reasonable. Remember: Our services are fast, friendly and efficient.





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    Improving Diversity in the Life Sciences Industry – Massachusetts Biotechnology Council, biotechnology industry.#Biotechnology #industry

    Improving Diversity in the Life Sciences Industry

    MassBio/Liftstream Report on Gender Diversity

    As part of our on-going efforts to improve diversity in the life sciences industry, MassBio partnered with Liftstream to develop a comprehensive study examining the cause behind the lack of gender diversity within the Massachusetts life sciences sector. This report, the most extensive of its kind, explores the experiences, motivations, and actions of both companies and employees to evaluate why gender gaps exist at every level of an organization, and offers a set of recommendations to improve gender diversity and inclusion.

    We view this report and its suggested actions as a launching pad toward real change across the industry. We ask that you join us as we move forward to a more diverse future.

    The report s findings challenge many long-held assumptions about gender diversity, while reinforcing many beliefs about why the problem persists and the best actions to remedy it. Here s a short sampling:

    • Women are taking initiative to advance their careers, at a rate higher than men, but without the same results.
      • 63% of C-level women reporting to change careers regularly to scale the ranks vs 21% of C-level men.
      • 38.7% of women at the SVP or VP level frequently ask for promotions vs 12.5% of men.
    • Women want to work at a diverse company and are willing to act upon their beliefs.
      • 46% of women say they d reject an employer because of having an all-male board, all-male management, and because they were interviewed only by men.
    • There is a major disconnect between what companies believe is working to improve diversity and what women see as happening in reality.
      • Only 9% of women viewing their companies as fully inclusive vs 40% of companies claiming this.

    In the coming weeks and months, MassBio and Liftstream will continue to engage with the life sciences community about this issue through varied initiatives and events. To be most effective, we must have a broad, diverse community behind us.

    Read the blog post and Q A for report highlights.

    For media inquiries or questions about the report and MassBio s initiative, please contact Jennifer Nason at MassBio





    Online Pharmacy, online pharmacy.#Online #pharmacy

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    What are the advantages if you decide to buy drugs online?

    Many things have changed when the Internet has entered our lives. We no longer send letters, but use emails; we are no longer restricted to just hearing the voices of our friends when we call them, since we can make a video call through Skype or Viber. Another thing that has drastically changed is the way we shop. Not only is it now possible to buy fashionable clothes over the Internet, it is also possible to buy drugs online. Not only does this allow people to purchase almost all the necessary medications without leaving the comfort of their homes, it can also make a huge difference for your budget.

    You see, when you go to the doctor, he’s not going to prescribe you a generic medication. Online purchase becomes the only way of acquiring affordable drugs in countries that do not allow people to simply go to the pharmacy and purchase what they wish. Some people may think that brand medications work better since they cost nearly ten times as much as generic medications. Fortunately, this is completely false. The reason why brand medications cost so much is because the company that developed the drug has spent millions and sometimes billions of dollars to do so. As you might imagine, after such an investment, the company would want to finally make some profit, and they do so in collaboration with doctors who prescribe only brand medications.

    Some people may wonder “Is it safe to buy drugs online?”. Their fears, however, are completely unsubstantiated. All the online pharmacies that sell brand and generic medications have to meet very strict safety standards. Moreover, all the data that you send to them while making your purchase gets securely encrypted to prevent anyone from accessing your private information. Thus, after you’ve made your purchase, you can rest assured that all is well and that soon will receive all your necessary meds not just for half the price, but for “tenth the price”.

    Affordability and convenience are not the only advantages of online pharmacies. International orders are also an option. Thus, no matter where you are, you can make a purchase and get your meds in the mail.

    Generic versus Brand name medications

    Many people wonder: “What is the difference between generic and brand name medications?” The answer is much simpler than you might expect. Their price! Yes, this is the only difference. However, upon hearing such a statement another question might arise: “How can a generic medication be ten times cheaper than the brand medication and be completely identical to it?” The answer to this question we will discuss below.

    The affordability of generic medications can be attributed to several factors. First and foremost, manufacturers of generic medications didn’t need to spend a cent on developing and marketing the new drug. People don’t realize just how long and how expensive it is to develop a new drug.

    • The first part begins with the search for the active substance, and after it is found – application for patent.
    • Then the effects and side effects of this active substance are studied on various kinds of animals. Though many nature-loving people are against animal testing, this step is necessary to prevent human deaths or life-crippling side effects when clinical trials will begin.
    • The final phase of pre-clinical studies is the authorization process of the new substance.

    These steps last from about 2 to 4 years and cost tens of millions of dollars.

    After a new substance was created, it is now time to test it on humans. The initial testing is divided into three phases to minimize the number of people affected by serious side effects:

    • Phase I – study of effects of the new drug on human subjects. Only 20-50 people are usually used for this phase. In the event that the drug will have serious, life-threatening side effects, the clinical trials will be discontinued.
    • Phase II – limited study. 50-100 patients are used.
    • Phase III – comparative studies. 500-5000 patients are participating.

    These three steps last 3 to 5 more years and cost on average one hundred million dollars.

    As you can see, the process of developing a new drug is long, arduous, and very costly, and we didn’t even mention the huge costs of marketing a new drug. Thus, it is unsurprising why the initial cost of brand medications is so high and why generic drugs are so affordable.





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    AAPS is the first Canadian College that designed, prepared and started to offer this ministry approved program in Canada.

    The Clinical Research, Drug Safety and Pharmacovigilance Diploma program is designed to develop specialized knowledge and skills required to design and write study protocols, monitor and manage clinical trials and to conduct drug safety and Pharmacovigilance activities including adverse reaction reporting and preparing periodic safety update reports. The program focuses on the global healthcare system as well as the Canadian healthcare system, Canadian regulatory agencies, health care legislation, international guidelines, and standard operating procedures (SOP). Using practical and current real cases, AAPS integrates a unique approach and provides students with the foundation and practical knowledge to formulate a sound clinical development plan; ensure clinical trial data is credible and accurate; and that the rights, integrity and confidentiality of trial subjects are protected.

    A well-trained and knowledgeable Clinical Research and Pharmacovigilance professional plays a vital role in protecting the study participant and the general population for marketed drugs and in helping to reduce the time between drug development and marketing approval. The demand for knowledgeable and trained Clinical Research and Pharmacovigilance professionals continues to grow, as supply is limited.

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    Biotech Industry, Biotech News, Biotechnology Articles, pharmaceutical research jobs.#Pharmaceutical #research #jobs

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    Certain microRNAs in the saliva of concussion patients could help gauge the severity of concussions and predict the length of concussion symptoms.

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    Toxicity knocks Ardelyx s hyperkalemia hopes back to preclinic

    Unexpected side effects have spelled the end for Ardelyx’s drug candidate to treat elevated potassium levels in the blood, which was in phase 3 testing.

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    Cytokinetics cans lead drug after phase 3 ALS wipeout

    Cytokinetics canned tirasemtiv after it failed to beat placebo against the primary endpoint or any of the secondary goals in an ALS trial.

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    Step Pharma bags cash for CTPS1 autoimmune R D drive

    The $17 million financing equips the lean French biotech to prepare its CTPS1 inhibitors for clinical testing in autoimmune disorders.

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    PTK6 blocker could treat or even prevent ER+ breast cancer metastasis

    The enzyme PTK6 could be targeted to quell the growth of estrogen receptor-positive breast cancer, a common form of the disease.

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    Amsterdam beats out Milan to host EMA

    After tying with Milan in a third round of voting, Amsterdam will be the new home of the European Medicines Agency.

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    LivaNova to offload Cardiac Rhythm unit for $190M

    LivaNova will sell its Cardiac Rhythm Management business to its joint venture partner, MicroPort Scientific.

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    DBV climbs as peanut allergy safety data come in clean

    Shares in DBV rose on the back of the data, going a little way to erasing the big drop it suffered after missing its primary efficacy endpoint.

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    Vos solutions nettoyantes pour toutes les surfaces optiques.

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    Mergers and Acquisitions in Pharmaceutical Sector, Economy Watch, irish pharmaceutical companies.#Irish #pharmaceutical #companies

    Mergers and Acquisitions in Pharmaceutical Sector

    July 16, 2010 • Mergers and Acquisitions • by EconomyWatch

    There are several causes of mergers and acquisitions in the global pharmaceutical industry. Among them are the absence of proper research and development facilities, gradual expiry of patents and competition within specific pharmaceutical genres. The high profile product recalls have also played a major role in the continuing mergers and acquisitions in the industry.

    Mergers and Acquisitions in Indian Pharmaceutical Sector

    In the Indian pharmaceutical market there are a number of companies that have entered into merger and acquisition agreements in the context of the global market scenario. These companies would be selling off the non-core business divisions like Over-the-Counter. This is expected to further the consolidation in the mid-tier as far as the pharmaceutical industry in Europe is concerned.

    The sheer number of companies acquiring parts of other companies has shown that the Indian pharmaceutical industry is ready to be a dominant force in this scenario. In the recent times Nicholas Piramal has taken the ownership of 17% of Biosyntech that is a major pharmaceutical packing organization in Canada.

    Torrent has got the ownership of Heumann Pharma, a general drug making company and, formerly, a subsidiary of Pfizer. Matrix has acquired Docpharma, a major pharmaceutical company of Belgium. Sun Pharmaceutical Industries is set to make acquisitions in pharmaceutical companies in the US and has set aside $450 million to execute these plans. In Bengaluru, Strides Arcolab has aimed at acquiring 70 percent in a pharmaceutical facility in Italy that is worth $10 million.

    Mergers and Acquisitions in European and Asian Pharmaceutical Sector

    As per several financial experts, the mergers and acquisitions in the pharmaceutical industry of Europe and India are meant to go on. In the Indian pharmaceutical scenario the mergers and acquisitions are supposed to go on a medium term. Factors like the execution of new patent regimen and companies dealing in specific pharmaceutical products are supposed to be the main driving factors behind the expected continuance of mergers and acquisitions in the Indian pharmaceutical market.

    Opportunities for Pharmaceutical Companies

    There are a number of opportunities for the major pharmaceutical products and services providers in the Indian pharmaceutical sector as the price controls have been relaxed and there have been significant changes in the medicinal requirements of the Indians. The manufacturing base in India is also strong enough to support the major international pharmaceutical companies from the performance perspective.

    This may be said as the Indian pharmaceutical market is varied as well as economical. It is expected that in the coming years the Indian pharmaceutical companies would be executing more mergers and acquisitions. It is expected that the regulated pharmaceutical markets in the United States and Europe would be the main areas of operation.

    In the recent years the Indian pharmaceutical companies have been venturing into mergers and acquisitions so that they can gain access to the big names of the international pharmaceutical scenario.

    Patterns of Mergers and Acquisitions in Pharmaceutical Sector

    One of the major features of the mergers and acquisitions in the pharmaceutical sector of the Asia-Pacific region has been the integration of the local pharmaceutical companies. This has happened especially in India and China. Acquisition has made it convenient for a number of companies to do business in various pharmaceutical markets.

    Previously the pharmaceutical markets of Europe were closed to the companies of other countries due to the difference in language. There were also other problems for companies like the trade barriers for instance.

    Figures of Mergers and Acquisitions in Pharmaceutical Sector

    As per the figures of mergers and acquisitions in pharmaceutical sector, from the year 2004, there have been more mergers and acquisitions in the pharmaceutical sector in the Asia-Pacific region compared to North America. The combined financial value of the mergers and acquisitions in Asia-Pacific region has been greater than North America.

    One of the major merger and acquisition deals in the Asia-Pacific region in the recent years has been the merger of Fujisawa and Yamanouchi in Japan. This deal was worth $7.9 billion. In the same period the Asia-Pacific region has experienced the highest percentage of growth in the mergers and acquisitions in pharmaceutical sector.

    In the same period the rate of growth in the Asia-Pacific region has been 37%. In Western Europe the rate of growth has been 11% and in North America it has been 20%. The pharmaceutical market in Eastern Europe has not experienced any increase in the rate of mergers and acquisitions.

    Mergers and Acquisitions in Global Pharmaceutical Sector

    Since the year 2004 there has been an increase in the mergers and acquisitions in the global pharmaceutical sector. This was reflective of the increase in the mergers and acquisitions in other industries at the same period. There was 20% increase in the number of deals, which stood at 1,808. There were eight deals with the value of more than $1 billion. This was three more than 2003.

    The total financial value of the deals was $112 billion and this was an increase of 53%. However, these figures do not include the acquisition of Aventis by Sanofi-Synthelabo that was worth $60 billion. This is the biggest acquisition in the pharmaceutical industry after the merger of Pharmacia and Pfizer in 2002.





    Pre-Requisites for Doctor of Pharmacy (Pharm D, pharma d.#Pharma #d

    University of the PACIFIC

    Join Pacific Admission on:

    Pre-Requisites for Doctor of Pharmacy (Pharm D.) Degree.

    A minimum of 68 semester units of college level coursework is required for admission to the Pharm D. program including all requirements listed below. All requirements must be completed, in progress, or planned before your application for admission will be reviewed.

    Important! Pacific will NOT accept online courses to fulfill science pre-requisites, public speaking, or to fulfill the biology/organic chemistry refresher requirements.

    Pacific is not able to perform a formal checklist of requirements until you apply and your application is complete. It is an advantage to apply early so you are assured all requirements have been met. Applicants who are missing a requirement will be notified of the missing pre-requisite and must respond with a plan to complete the requirement. Students have through the summer term prior to entrance to meet our pre-requisites. Once your plan has been approved, your file will be reviewed.

    If you attend a school that is not listed, please seek advising from your school to determine if you have enrolled in the biology and chemistry sequences designed for biology and chemistry majors at your institution.

    Calculus – *One semester or 2 quarters of college level calculus. (An AP exam with a score of 4 or 5 can be substituted.) *Two semesters are required if techniques of integration is not covered until the second semester calculus at your school. *Please check the articulation with your school to determine what course(s) fulfill the requirement.

    Physics – One semester or 1 quarter of college level physics with lab. (An AP exam with a score of 4 or 5 can be substituted.)

    General Chemistry – Two semesters or 3 quarters with labs in each term. Should be a course sequence designed for chemistry majors. (Pacific does not accept AP for this requirement.) *Please check the articulation agreement with your school to determine if your sequence meets our requirement.

    Organic Chemistry – Two semesters or 3 quarters with labs in each term. Should be a course sequence designed for chemistry or biology majors. *Please check the articulation agreement with your school to determine if your sequence meets our requirement. Students who have not enrolled in two semesters/three quarters of organic chemistry within the last seven years, of the anticipated entrance date into our program, are required to enroll in one year of organic chemistry with labs to refresh in this area.

    General Biology – Two semesters or 3 quarters with labs in each term. Should be a course sequence designed for biology majors. (Pacific does not accept AP for this requirement.) *Please check the articulation agreement with your school to determine if your sequence meets our requirement. Students who have not enrolled in two semesters/three quarters of biology within the last seven years, of the anticipated entrance date into our program, are required to enroll in two semesters of biology with labs as a refresher in this area. (Genetics, Microbiology, Cell Biology, Physiology, and Anatomy are acceptable for refresher courses as long as the general biology requirement has been completed.)

    Human Physiology – One semester or quarter with lab is required. It should be a course designed for biology majors.

    Microbiology – One semester or one quarter course. (Lab recommended but not required)

    English Composition* – Minimum of two 3-semester unit courses or two 4-quarter unit courses. English as a Second Language courses will not fulfill this requirement. This should be the freshman composition sequence (equivalent to ENGL 1A and 1B). This requirement must be completed at an accredited institution in the United States or at an accredited institution in a predominately English speaking country. (An AP Exam score of 4 or 5 will fulfill this requirement. One exam is needed per semester. **Limitations apply)

    Public Speaking* – Minimum of one 3-semester unit course or one 4-quarter unit course. Interpersonal communication DOES NOT fulfill this requirement. It must specifically be a public speaking course. (This course also fulfills University of the Pacific General Education Category IIA). This requirement must be completed at an accredited institution in the United States.)

    Economics* – Minimum of one 3-semester unit course or one 4-quarter unit course. (Principles of Economics or Macroeconomics will also fulfill University of the Pacific General Education Category IB) (An AP Exam with a score of 4 or 5 will fulfill this requirement. **Limitations apply)

    Please Note: Microeconomics will be accepted IF you complete your Bachelor’s Degree prior to entering our program or you have completed a course in U.S. History or Introductory Sociology.

    Psychology* – Minimum of one 3-semester unit course or one 4-quarter unit course. Must be a course in General or Introductory Psychology, or Abnormal Psychology. (This course also fulfills University of the Pacific General Education Category IA). (An AP Exam with a score of 4 or 5 will fulfill this requirement. **Limitations apply).

    General Education* – At least one 3-semester unit course from general education category IC, IIB, and IIC. These are sample courses; others may be acceptable. Students who have, or will have, earned a U.S. Bachelor’s degree are exempt from completing categories IC, IIB, and IIC; however, are still required to meet the 28 semester/42 quarter units of liberal arts in non math or sciences courses. (see more information below).

    **Appropriate AP exams with scores of 4 or 5 are acceptable to fulfill GE requirements but limitations apply.

    (Fulfilled by Principles of Economics or Macroeconomics)





    European Pharmaceutical Market Research Association, EphMRA, pharmaceutical research.#Pharmaceutical #research

    pharmaceutical research

    Pharmaceutical research

    Welcome to EphMRA

    We are a hub for excellence in research thinking to empower healthcare market researchers to provide consultancy to the business.

  • Pharmaceutical research

    The 2017 Conference will take place in

    Amsterdam – 20 – 22 June

  • Pharmaceutical research

    2016 Anatomical Classification Guides

    are now available.

  • Pharmaceutical research

    Join EphMRA

    Become part of the Association – find out more here:

  • Pharmaceutical research

    Advertise with EphMRA

    On the website and in the eNews

    Our Vision

    Pharmaceutical research

    Creating excellence in professional standards and practices to enable healthcare market researchers to become highly valued business partners.

    • Pharmaceutical research
    • Pharmaceutical research

    Pharmaceutical research Pharmaceutical research

    Pharmaceutical researchLatest News

    Pharmaceutical researchUpcoming Events

    • EphMRA one day meeting in UK 27 February 2018

    27th February 2018

    17th April 2018

    26 – 28 June 2018

    Pharmaceutical researchLatest from Twitter

    Keep up to date with EphMRA and member news

    Advertise with EphMRA

    Web site (home page) banner, eNews adverts and Conference sponsorship/advertising packages are available – all tailored to suit your needs.





  • Bio Pharma Logistics – When it matters, bi pharma.#Bi #pharma

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    Bi pharma

    Bio Pharma Logistics. When it matters!

    Our company is specialised in (bio) pharmaceutical shipments & clinical trials, warehousing and added-value services and has been a reference for many years in this niche market. For more than a decade we have been preferred supplier of many high-end (bio) pharma chemical companies. As an independent, ethical and multimodal company, with a worldwide network of agents, our customers can rely on our expertise, global reach and experience.

    For more than 20 years, we have served our customers thanks to our well trained staff, high quality services and the ability to provide tailored, creative and competitive logistics solutions. All of our staff members, from drivers, to handlers, to administrative personnel and agents are trained to the specific needs of the pharmaceutical sector. Bio Pharma Logistics is ISO 14001 & ISO 9001 certified and all of our procedures are in compliance with cGxP requirements.

    Flexibility and responsiveness: that is what the fast-moving (bio)pharmaceutical, life sciences and chemical industry needs from its suppliers and that is exactly what Bio Pharma Logistics delivers!

    Accreditations Certifications

    Bi pharma

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  • CMA: ЙTUDE ET RЙALISATION DE MACHINES SPECIALES POUR L INDUSTRIE PHARMACEUTIQUE, pharma d.#Pharma #d

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    ЙTUDE ET RЙALISATION DE MACHINES POUR LES PROCESSUS DE FABRICATION PHARMACEUTIQUES, CHIMIQUES ET COSMЙTIQUES

    Pharma d

    Leader sur le marchй de l’йquipement des industriels de la pharmacie, CMA doit sa notoriйtй а ses avancйes techniques, au savoir faire de ses compagnons et а une longue pratique des mйtiers de la pharmacie.

    Une crйativitй constante, l’optimisation de la qualitй et le suivi de la production font de CMA une rйfйrence dans l’йquipement des industries pharmaceutiques.

    Pharma d

    Pharma d

    Pour mener а bien les projets qui lui sont confiйs, le bureau d’йtude de CMA conзoit ses produits dans le respect des normes en vigueurs (CE, BPF, GMP, GAMP, ATEX, CFR21 part 11 . ).

    Pharma d

    Pour aider ses clients а valider leur choix CMA dispose de diffйrents appareils pilotes destinйs а rйaliser des essais.

    Pharma d





    Dosage Forms, Pharmaceutical Technology, pharmaceutical dosage forms.#Pharmaceutical #dosage #forms

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    Pharmaceutical dosage formsPharmaceutical dosage forms

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    Columnists

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    Webcasts

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    Pharma trends translate into increased need for not only external partners, but those will capabilities that can help advance today’s drug development and manufacturing challenges.

    CDMO Acquisitions Build Strategic Supplier Base

    Recent acquisitions are creating CDMOs with scale that rivals global bio/pharma.

    Kurmann Partners Develop Interactive Map of Manufacturing Sites

    The M ?>

    Home Page, PhRMA, how big is the pharmaceutical industry.#How #big #is #the #pharmaceutical #industry

    how big is the pharmaceutical industry

    PhRMA represents the country’s leading biopharmaceutical research companies and supports the search for new treatments and cures.

    Advocacy

    From accessing medicines to intellectual property to drug safety, PhRMA is devoted to advancing public policies that support innovative medical research, improve treatments and yield real results.

    Science

    Today, cutting-edge medical science is transforming patients’ lives. Discover how scientists and researchers are advancing science.

    Patients

    Patient support and assistance is the top priority for PhRMA’s member companies, who are working hard to improve patients’ lives through the discovery and development of new medicines and treatments.

    Resources

    Explore the Resource Library, the interactive State Map and the Chart Pack reports.

    Search the PhRMA Network

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    Sign Up for Updates

    How big is the pharmaceutical industry

    Welcome to the future of medicine. Where together, we go boldly.

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    PPA strives to improve patient health, advance medical innovation and fuel economic growth.

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    The PhRMA Foundation supports the research and career endeavors of scientists in drug discovery and development.

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    Access Better Coverage educates consumers about the ABCs of health coverage and access to medicines.

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    Learn more about America’s biopharmaceutical companies and how they seek to improve patients’ lives.

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    We Work For Health aims to increase awareness by uniting workers throughout the industry.

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    Patent protection should always be considered by an inventor during the initial stages of their invention.

    How big is the pharmaceutical industry

    Working to spread awareness and education about the importance of secure drug disposal.





    Determination of sodium hyaluronate in pharmaceutical formulations by HPLC–UV, pharmaceutical formulations.#Pharmaceutical #formulations

    pharmaceutical formulations

    Pharmaceutical formulations

    Journal of Pharmaceutical Analysis

    Pharmaceutical formulations

    Abstract

    A liquid chromatography (HPLC) method with UV detection was developed for determination of sodium hyaluronate in pharmaceutical formulation. Sodium hyaluronate is a polymer of disaccharides, composed of d -glucuronic acid and d -N-acetylglucosamine, linked via alternating β-1, 4 and β-1, 3 glycosidic bonds. Being a polymer compound it lacks a UV absorbing chromophore. In the absence of a UV absorbing chromophore and highly polar nature of compound, the analysis becomes a major challenge. To overcome these problems a novel method for the determination of sodium hyaluronate was developed and validated based on size exclusion liquid chromatography (SEC) with UV detection. An isocratic mobile phase consisting of buffer 0.05 M potassium dihydrogen phosphate, pH adjusted to 7.0 using potassium hydroxide (10%) was used. Chromatography was carried out at 25 °C on a BioSep SEC S2000, 300 mm×7.8 mm column. The detection was carried out using variable wavelength UV–vis detector set at 205 nm. The compounds were eluted isocratically at a steady flow rate of 1.0 mL/min. Sodium hyaluronate retention time was about 4.9 min with an asymmetry factor of 1.93. A calibration curve was obtained from 1 to 38 g/mL (r 0.9998). Within-day % RSD was 1.0 and between-day % RSD was 1.10. Specificity/selectivity experiments revealed the absence of interference from excipients, recovery from spiked samples for sodium hyaluronate was 99–102. The developed method was applied to the determination of sodium hyaluronate in pharmaceutical drug substance and product.

    Keywords

    Peer review under responsibility of Xi an Jiaotong University.

    Pharmaceutical formulations

    1. Download full-size image




    PCD Pharma Franchise, Third Party Manufacturing, Biophar Lifesciences, pharmaceutical formulations.#Pharmaceutical #formulations

    Biophar

    PCD Pharma Franchise

    Welcome to Biophar Lifesciences

    We are a renowned manufacturer & supplier of pharmaceutical drugs which find their application in the medical sector & allied areas. The product line includes Tablets, Capsules, Injections, Ayurvedic Medicines, Syrups, Softgel, Creams & Powders and Dental Solutions. Our capabilities also lie in assisting the clients to formulate guidelines that allow them to promote their products in the market, and further increasing their presence. PCD pharma company, franchise in Chandigarh, Manimajra, Punjab, Himachal, INDIA Our range is well known throughout the market for its quality, effectiveness, accurate composition, chemical ratio and exceptional medicinal properties. The range available with us highly appreciated by the clients, and is well received in the domestic market. Through our products, we are successfully serving the requirements of numerous reputed organizations, and provide excellent cures for many fatal diseases, thereby helping the whole community. We are amongst top PCD pharma company. Contact us for pharma franchise in Chandigarh, Manimajra, Punjab, Himachal, INDIA. Business Specifics:: Nature of business: Trader and Supplier. Location: Chandigarh (India)

    PCD Pharma Franchise

    We are giving Monopoly rights through Pharma Franchise on PCD (Propaganda cum distribution) basis in all states of India.

    Pharmaceutical formulations

    Pharmaceutical formulations

    With years of experience, we are able to offer a wide range of Soft gels, Capsule, Tablets and Syrups. Our pharmaceutical products are formulated using quality material, which is sourced from reliable and trusted manufacturers with ISO Certified and GMP compliance Units.

    To meet the bulk requirements of our clients we have sophisticated own manufacturing unit, which is well equipped with the advanced machines. Moreover, we also have testing machines for checking the quality of our chemicals and drugs..

    We have implemented logistic operation and quality control method as per the international standards. As a result, we cater to the demands of a large clientele base across the world. We welcome Qualified and experienced individuals as well as Corporates from all over India to become our associates through PCD Pharma Franchise. We offer to them good quality medicines at the most competitive rates in India.

    Third Party Manufacturing

    We are engaged in contract manufacturing Services of wider range of tablets , capsules, injectables, dry syrups, Nutraceuticals.

    Pharmaceutical formulations

    Pharmaceutical formulations

    As leading contract manufacturer in northern India with state of the art manufacturing facilities in tax free zone, with commitment towards working collaboratively with our customers. We are having capacity for large scale productions of tablets, capsules, dry syrups, syrups, neutraceuticals and injections.

    We uphold quality measures at all stages from material procurement, process optimization, formulation, testing and stability. Large scale production capacity and qualified & experienced production and quality control staff are a perfect combination at theon pharmaceuticals limited for sufficing the outsourcing or third party manufacturing requirements.

    own manufacturing facility





    Pharmaceutical distributors, pharmaceutical distributors.#Pharmaceutical #distributors

    We do all the work. You get the Credit!

    Pharmaceutical distributors

    Many times, making a change in your pharmaceutical returns process could result in an increase of thousands of dollars in cash back to your pharmacy.

    Rx Reverse Distributors has earned a reputation in the industry for maximizing return credit on all expiring or unwanted pharmaceuticals, while making the process surprisingly uncomplicated.

    Maximum Return, Minimum Hassle

    Unlike other return services in the industry, RxRD is exceedingly persistent in identifying and recovering the maximum amount of cash credit for your expired and unwanted pharmaceuticals. RxRD makes the process simple with no product exclusions, no invoices, no out-of-pocket expenses, and no contract terms.

    Unparalleled Support

    Every RxRD customer is assigned a dedicated support representative who will regularly analyze your account to maximize your return value. These service professionals are available to answer questions, alert you of return timelines, and assist in the inventory and tracking process.

    Rapid Turnaround

    Through leading-edge tracking technology and efficient internal processing practices, RxRD typically processes pharmaceutical returns quicker than the industry average. RxRD has long-standing partnerships with the Nation s leading manufacturers, wholesalers, and buying groups. The RxRD accounting team will follow-up with ALL of them until you get the full the credit possible for returned products.

    Comprehensive Reporting

    All transactions with RxRD are transparent and uncomplicated. You will be provided with easy-to-read inventory reports detailing your estimated cash return amount once we receive your shipment. After our team works diligently to get the maximum amount of cash from your returns, you will also receive a monthly cash statement, eliminating confusing wholesaler reconciliation reports.

    User-Friendly Technology

    As an innovator in pharmaceutical returns and inventory technology, RxRD develops software and online applications that are simple for anyone to use. For those customers using the online portal, the returns process is guided step-by-step. There, you can download forms and shipping labels, print reports, schedule pickup, and even track the progress of your return.

    Personalized Programs

    As a family-owned and customer-focused company, RxRD offers various levels of service depending on the needs of your pharmacy. With the convenience of in-house or on-site services, the specialists at RxRD can help you find the program that is the right fit for your operation and budget.





    Dosage Forms, Pharmaceutical Technology, pharmaceutical dosage forms.#Pharmaceutical #dosage #forms

    pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage formsPharmaceutical dosage forms

    Top News

    EMA to Relocate to New HQ in Amsterdam in Wake of Brexit

    FDA Approves Digital Pill

    FDA to Recognize Inspections from EU Drug Authorities

    UBM Announces BioLive Event

    FDA Commissioner Testifies Before House Committee About the Agency’s Efforts to Combat the Opioid Crisis

    Columnists

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Pharmaceutical dosage forms

    Webcasts

    Risk Assessment and Testing Requirements for Elemental Impurities in Pharmaceutical Products

    The Journey to a Successful Biologic License Application

    Partnership of Chemical Engineers and Chemists Optimizes Process Development

    Outsourcing

    Small and Specialty Companies Shape Pharma’s Evolving Outsourcing Landscape

    Pharma trends translate into increased need for not only external partners, but those will capabilities that can help advance today’s drug development and manufacturing challenges.

    CDMO Acquisitions Build Strategic Supplier Base

    Recent acquisitions are creating CDMOs with scale that rivals global bio/pharma.

    Kurmann Partners Develop Interactive Map of Manufacturing Sites

    The M ?>

    PCD Pharma Franchise, Third Party Manufacturing, Biophar Lifesciences, pharmaceutical formulations.#Pharmaceutical #formulations

    Biophar

    PCD Pharma Franchise

    Welcome to Biophar Lifesciences

    We are a renowned manufacturer & supplier of pharmaceutical drugs which find their application in the medical sector & allied areas. The product line includes Tablets, Capsules, Injections, Ayurvedic Medicines, Syrups, Softgel, Creams & Powders and Dental Solutions. Our capabilities also lie in assisting the clients to formulate guidelines that allow them to promote their products in the market, and further increasing their presence. PCD pharma company, franchise in Chandigarh, Manimajra, Punjab, Himachal, INDIA Our range is well known throughout the market for its quality, effectiveness, accurate composition, chemical ratio and exceptional medicinal properties. The range available with us highly appreciated by the clients, and is well received in the domestic market. Through our products, we are successfully serving the requirements of numerous reputed organizations, and provide excellent cures for many fatal diseases, thereby helping the whole community. We are amongst top PCD pharma company. Contact us for pharma franchise in Chandigarh, Manimajra, Punjab, Himachal, INDIA. Business Specifics:: Nature of business: Trader and Supplier. Location: Chandigarh (India)

    PCD Pharma Franchise

    We are giving Monopoly rights through Pharma Franchise on PCD (Propaganda cum distribution) basis in all states of India.

    Pharmaceutical formulations

    Pharmaceutical formulations

    With years of experience, we are able to offer a wide range of Soft gels, Capsule, Tablets and Syrups. Our pharmaceutical products are formulated using quality material, which is sourced from reliable and trusted manufacturers with ISO Certified and GMP compliance Units.

    To meet the bulk requirements of our clients we have sophisticated own manufacturing unit, which is well equipped with the advanced machines. Moreover, we also have testing machines for checking the quality of our chemicals and drugs..

    We have implemented logistic operation and quality control method as per the international standards. As a result, we cater to the demands of a large clientele base across the world. We welcome Qualified and experienced individuals as well as Corporates from all over India to become our associates through PCD Pharma Franchise. We offer to them good quality medicines at the most competitive rates in India.

    Third Party Manufacturing

    We are engaged in contract manufacturing Services of wider range of tablets , capsules, injectables, dry syrups, Nutraceuticals.

    Pharmaceutical formulations

    Pharmaceutical formulations

    As leading contract manufacturer in northern India with state of the art manufacturing facilities in tax free zone, with commitment towards working collaboratively with our customers. We are having capacity for large scale productions of tablets, capsules, dry syrups, syrups, neutraceuticals and injections.

    We uphold quality measures at all stages from material procurement, process optimization, formulation, testing and stability. Large scale production capacity and qualified & experienced production and quality control staff are a perfect combination at theon pharmaceuticals limited for sufficing the outsourcing or third party manufacturing requirements.

    own manufacturing facility





    Life-cycle Documentation – Computer Systems Validation, pharmaceutical process validation.#Pharmaceutical #process #validation

    pharmaceutical process validation

    At this stage of the project an initial risk assessment should be performed. This is a high level assessment based on the overall risk to Product Quality, Patient Safety and Data Integrity. The output of the assessment should support the selction of the system and the validation requirements and be documented within the Computer Systems Validation Plan.

    Supplier Audit

    Regulations require that software is designed to a quality system (EU Annex 11).

    “The software is a critical component of a computerised system. The user of such software should take all reasonable steps to ensure that it has been produced in accordance with a system of Quality Assurance.”

    For a computer system with bespoke software (GAMP 5 category 5) some evaluation of the software supplier must be performed. The level of assessment should be based of the initial risk assessment.

    Computer System Validation Planning

    • Specification (User Requirements and Functional Design Specifications)
    • Design Review
    • Risk Assessments
    • Testing and Verification
    • Operational Compliance

    Design and Build

    The design and build phase is normally under the control of the supplier.

    Design Documents

    The minimum design documents required for a Computerise Process Control System are:

    • Functional Design Specification
    • Electrical Wiring Schematics
    • Instrument Loop Diagrams

    These should provide sufficient detail to the regulated company that the system will be designed to meet the User Requirements.

    Design Review

    The design review process should ensure that all the supplied documents are clear, concise and fit for purpose. This is a critical phase in the project as the design is approved the supplier starts the software development and build process.

    The design review may be carried out in phases and the process is normally summarised in a Design Review Report.

    Traceability between the requirements should be produced during the design review phase. This document in its initial phase can act as a test plan, identifying the testing stage that the function will be tested.

    Risk Assessment

    Identifying both quality and business risks at the design phase offers the opportunity to improve the design, design out risk. Also the Functional Risk Assessment supports the planning of testing, development of a mitigation plan and communication of risk.

    Verification and Release

    The level of testing should be dependant on the documented risk assessments.

    A test plan (based on the RTM) should identify the levels of testing. For less critical functions less formal testing may be performed, in accordance with Good Engineering Practices (GEP), with critical quality attributes having more formalised testing.

    Formal release of the equipment for GMP use should be via a Validation Summary Report. This report should clearly summarise each phase of the implementation / validation lifecycle. Any failures or limitations in use should be detailed.

    The Validation Summary Report should also clearly define the process limits of testing (the range for which the equipment is qualified to perform).

    Operational Compliance

    Operational compliance should be considered throughout the development of the system. This includes development of Standard Operating Procedures for the Use, Maintenance and administration of the system.

    In addition the Periodic Quality Review frequency should be set. For new systems with bespoke software I would recommend having a shorter time for the review frequency with this extended once the system has been demonstrated as stable.





    Solubility profile, Stability profile, Reformulation, 505(b)2, Deformulation, pharmaceutical dosage forms.#Pharmaceutical #dosage #forms

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    Welcome to LATITUDE Pharmaceuticals

    Formulation Experts for Insoluble Compounds

    LATITUDE Pharmaceuticals Inc. is a leading-edge boutique contract research organization that provides innovative drug formulation services and proprietary drug delivery systems to the human and veterinary pharmaceutical industries. Since our founding in 2003, we have performed over 750 formulation development projects for over 200 client companies and have developed a world-wide reputation for creative approaches, reliability, rapid turnaround, successful formulations and client satisfaction.

    LATITUDE’s focus is on the special challenges of formulation development for compounds that are highly insoluble, highly unstable, and/or have poor bioavailability. This focus has made LATITUDE a specialist with the experience and track record to tackle the toughest formulation challenges for problematic drug candidates.

    LATITUDE employs a wide armamentarium of techniques and technologies, many of which are unique and proprietary, to address insolubility, instability, poor absorption, vein irritation, large/bulky doses, lack of IP protection and other formulation challenges over a wide range of pharmaceutical dosage forms.

    LATITUDE also develops state-of-the-art drug delivery systems as proprietary platform formulation technologies , including our PG Depot™ injectable depots and our Nano-E™ nano-emulsions. Latitude makes these technologies available to our clients to improve the efficacy, safety, and overall therapeutic value, as well as establish new intellectual property, for their drug compounds.

    In addition, LATITUDE applies its own technologies to develop improved formulations of existing drugs that can be developed as accelerated-approval 505(b)(2) NDA candidates. Contact LATITUDE for more information on these Licensing Opportunities.

    In servicing the formulation challenges of biotech and pharmaceutical companies, LATITUDE has grown by building a strong repeat business while providing excellent services to our clients. Contact us for more information and to discuss how LATITUDE can address your drug formulation needs.





    Key Considerations in Excipients Selection for Solid Dosage Forms, Pharmaceutical Technology, pharmaceutical dosage forms.#Pharmaceutical #dosage

    pharmaceutical dosage forms

    The majority of pharmaceutical drugs are still produced as solid dosage forms because of the acceptability and convenience of the oral route as well as the good patient compliance it offers in general. As solid dosage forms do not require sterile manufacturing conditions, the overall production costs are less expensive. Moreover, the pharmaceutical industry has years of experience developing solid dosage forms with well-defined and known processes, equipment, and technologies.

    To gauge emerging trends in solid dosage manufacturing, Pharmaceutical Technology spoke with Randy Wald, senior research fellow at Bend Research, part of Capsugel Dosage Form Solutions about key drivers shaping the pharmaceutical drug development and manufacturing landscape.

    PharmTech: How has the manufacture of solid dosage forms changed over the past decade?

    Wald: The manufacture of solid dosage forms continues to evolve, with key drivers including functional improvements, safety, and overall cost of development and commercial manufacture.

    Several key trends can be noted, all of which continue and include increased partnership of CDMO/CMO with pharmaceutical companies, increased demand for specialized dosage forms (pediatric/geriatric, abuse-deterrent, fixed dose combinations), higher potency APIs in the development pipeline and in commercial production, the maturation of solubility-enhancing technologies, increasing prevalence of continuous manufacturing processing displacing legacy batch processing, and continued advances in excipients including ready-to-use and co-processed.

    The outsourcing of pharmaceutical development and/or manufacturing to CDMO/CMOs has become mainstream given the continued trends of pharmaceutical company downsizing and focusing on molecule discovery and marketing functions, the increasing role of small/virtual pharmaceutical companies in drug discovery and development, and the demand for increasingly innovative drugs using specialized technologies.

    Continuous processing, where multiple continuous unit operations are coupled into an integrated system, improves overall productivity and costs of production and is complimentary with ICH and other quality-by-design paradigms. Continuous processing, such as continuous coating, has been implemented in immediate-release capsules and tablets (initially in the health nutrition segment and, in past few years, there has been fast growth in Rx/OTC). It will continue to find applications in the pharmaceutical segment inclusive of more specialized areas such as extended-release drug products.

    We are also seeing functional improvements using existing pharmaceutically approved excipients. Given the prohibitive cost of developing and gaining approval for a new excipient, suppliers have coupled processing advances for the development of innovative dosage forms. Several examples can be cited:

    • Coupling of processing and polymer chemistry to greater effect, e.g., melt-spray-congeal processing to encapsulate API in a lipid matrix, the architecture of which is tailored to meet the functionality required whether it is bioavailability enhancement, controlled release, and/or taste masking.
    • Use of functional capsules incorporating approved enteric polymers to eliminate previously required coating steps to provide gastric resistance or fully enteric protection for solid oral dosage forms. The elimination of functional coating can speed up and de-risk the development process for actives requiring enteric protection and/or targeted release in the upper GI tract.
    • Use of existing excipients and processing to provide abuse resistance for opioids and other often-abused drugs, which is increasingly required by regulatory authorities. By understanding the typical routes of abuse, resistance is being built into drug products using a range of excipient functionality inclusive of thickening agents, waxy or high melting point excipients and taste modifiers.
    • Additional functionality built into existing excipients, e.g., additional grades of pharmaceutically approved excipients to provide more tailored functionality and/or improved supply-chain performance such as shelf life. Examples include new polymer grades for hot-melt extrusion and spray dry dispersion processing (e.g., more molecular weight and viscosity grades for cellulosic polymers). Co-processing of approved excipients for greater functionality and simpler manufacturing is another trend.
    • Drug design and manufacture for specialized populations including pediatric and geriatric applications where patient compliance is a challenge. Reducing the number of medications and/or dosing frequency, coupled with improving the ease of swallowing, is increasingly factored in and drives more fixed dose combinations, extended release, and multiparticulate formulations.

    PharmTech: Excipients make the bulk of a solid dosage form and they play an important role in properties of the finished formulation, such as its stability, drug release, bioavailability, taste, and texture. When it comes to formulation development, what are the key considerations when selecting your excipient for a solid dosage form?

    Wald: Functional excipients form the foundation of most solid oral dosage forms and as such, careful consideration must be taken in their selection. The possible consequences of sub-optimized excipient selection can include reduced bioavailability, compromised stability, manufacturing complications, and increased chance of side effects, which affect the overall commercial success of the drug. We have developed decision trees and models, based on more than a thousand compounds, to guide the choice of appropriate technology and excipients for key challenges such as bioavailability and controlled release.

    Key technological considerations include:

    • The product s desired pharmacokinetic performance (PK modeling)
    • Functional excipients for enhanced absorption, controlled or modified release, API stability, etc.
    • Dose levels
    • API physical/chemical properties

    Commercial considerations are also factored in, such as the desired finished dose presentation. This process greatly narrows the choice of excipients preferred for the technology and manufacturing processing.

    PharmTech: In terms of excipients for solid dosage forms, what are the key advances that have significantly impacted the formulation development and manufacturing process of solid dosage forms?

    Wald: Excipient suppliers continue to respond to both regulatory and industry trends by providing additional grades of existing excipients as well as new and/or co-processed excipients. Key requirements include enhanced excipient functionality and range to assist in repositioning existing compounds for greater efficacy and/or new indications. For preclinical evaluations, speed, and de-risking are key considerations. And simplified formulation and processing approaches are increasingly important. A few examples are listed in the following:

    • Additional grades of hypromellose acetate succinate (HPMCAS) have been developed to expand the range and applicability of spray dry dispersion technology for addressing low solubility.
    • Lipid multiparticulate (LMP) technology has been developed to provide the functionality of lipid-based formulations and the benefits of the multiparticulate format an example of leveraging lipid-based formulation and melt-spray congeal processing know-how to achieve innovation with existing excipients.
    • New polymers and grades have been developed specifically for hot melt extrusion processing, based on increased understanding of the process and requirements.
    • Dry dispersion formats of existing polymers have been developed for ease of processing and reduced costs.
    • Functional capsule technology developed to intrinsically provide enteric protection, eliminating the need for functional coatings and the complexity and risk associated with their application.
    • Co-processing to provide multi-functionality and/or improved functionality using a single excipient for early stage development through commercial production.

    PharmTech: Do you see a need for novel excipients and if so, what excipients?

    Wald: Continued advances not necessarily novel excipients in excipient formulation and processing technology are required to keep pace with the increasing challenges in drug product formulation and production. As an example, the drug pipeline challenge continues with an increasing percentage of poorly soluble and higher molecular weight molecule candidates. Thus, excipient functionality that provides both enhanced absorption and extended release is a promising area. Another example is the move towards continuous processing. Excipient vendors will increasingly need to supply excipient types and grades amenable to new processing versus historic batch processing.





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    Verona Pharma Doses First Patients in Phase 2b Clinical Trial of RPL554 for COPD Maintenance

    Verona Pharma Doses First Patients in Phase 2b Clinical Trial of RPL554 for COPD Maintenance Treatment

    LONDON , July 26, 2017 (GLOBE NEWSWIRE) — Verona Pharma plc (AIM:VRP) (NASDAQ:VRNA) (“Verona Pharma”), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative therapies for respiratory diseases, announces today that the first patients have been dosed in a Phase 2b clinical trial evaluating RPL554 as a maintenance treatment for chronic obstructive pulmonary disease (“COPD”). Verona Pharma expects to report top-line data from this trial in the second half of 2018.

    RPL554 is a first-in-class, inhaled, dual inhibitor of the enzymes phosphodiesterase 3 and 4 designed to have anti-inflammatory, as well as bronchodilator properties, and is currently in development for the treatment of COPD and cystic fibrosis.

    The four-week, dose-ranging trial is planned to enroll approximately 400 patients with COPD to investigate the efficacy, safety, and dose-response of nebulized RPL554 as a maintenance treatment for the disease. The primary endpoint of this double-blind, placebo-controlled, parallel group study is improvement in lung function with RPL554 compared to placebo, as measured by FEV1, a standard measure of exhaled breath volume used to evaluate respiratory function.

    The trial is being performed at a number of sites across Europe and is part of Verona Pharma’s global strategic services agreement with QuintilesIMS to provide core clinical trial services for RPL554 clinical development programs, as well as provide additional insights to inform development and commercial strategy.

    “Dosing our first patients in this larger four-week Phase 2b trial is an important step forward in the evaluation of nebulized RPL554 as a novel therapy for COPD patients with significant unmet medical needs,” said

    , PhD, CEO of Verona Pharma . “The clinical data generated to date and the mechanism of action of RPL554 makes it a promising first-in-class treatment option. We look forward to working with patients and healthcare providers across the trial sites to gather meaningful data and insights, and expect to report top-line results from this study in the second half of 2018.”

    In previous clinical trials in patients with COPD, RPL554 has been observed to result in statistically significant improvements in lung function as compared to placebo and has shown clinically meaningful and statistically significant improvements in lung function when added to two commonly used bronchodilators as compared to either bronchodilator administered as a single agent. RPL554 has also shown anti-inflammatory effects and has been well tolerated in clinical trials.

    About Chronic Obstructive Pulmonary Disease

    Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease for which there is no cure. The condition damages the airways and the lungs, leading to cough, mucus secretion and shortness of breath, impacting a person’s ability to perform daily activities. According to the World Health Organization , COPD is the third leading cause of death globally, with 210 million people worldwide suffering from the disease. Current therapies to treat COPD are aimed at reducing and controlling symptoms. Despite the wide availability of these therapies, many COPD patients continue to suffer acute periods of worsening symptoms known as exacerbations. In the U.S. alone, these exacerbations are associated with approximately 1.5 million emergency department visits, 687,000 hospitalizations, and 129,000 deaths per year. The total annual medical costs related to COPD in the U.S. were estimated to be $32 billion in 2010, and are projected to rise to $49 billion in 2020.

    Verona Pharma is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative therapies for the treatment of respiratory diseases with significant unmet medical needs.

    Verona Pharma’s product candidate, RPL554, is a first-in-class, inhaled, dual inhibitor of the enzymes phosphodiesterase 3 and 4 that acts as both a bronchodilator and an anti-inflammatory agent in a single compound. Verona Pharma is developing RPL554 for the treatment of chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), and potentially asthma.

    This press release contains forward-looking statements. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, statements regarding the design of the Phase 2b clinical trial of RPL554, the timing of availability of top-line data for the Phase 2b clinical trial, the importance of the Phase 2b clinical trial to our development plans for RPL554, the potential of RPL554 as a promising first-in-class treatment option for COPD, and the value of the data and insights that may be gathered from the Phase 2b clinical trial.

    These forward-looking statements are based on management’s current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from our expectations expressed or implied by the forward-looking statements, including, but not limited to, the following: our limited operating history; our need for additional funding to complete development and commercialization of RPL554, which may not be available and which may force us to delay, reduce or eliminate our development or commercialization efforts; the reliance of our business on the success of RPL554, our only product candidate under development; economic, political, regulatory and other risks involved with international operations; the lengthy and expensive process of clinical drug development, which has an uncertain outcome; serious adverse, undesirable or unacceptable side effects associated with RPL554, which could adversely affect our ability to develop or commercialize RPL554; potential delays in enrolling patients, which could adversely affect our research and development efforts; we may not be successful in developing RPL554 for multiple indications; our ability to obtain approval for and commercialize RPL554 in multiple major pharmaceutical markets; misconduct or other improper activities by our employees, consultants, principal investigators, and third-party service providers; material differences between our “top-line” data and final data; our reliance on third parties, including clinical investigators, manufacturers and suppliers, and the risks related to these parties’ ability to successfully develop and commercialize RPL554; and lawsuits related to patents covering RPL554 and the potential for our patents to be found invalid or unenforceable. These and other important factors under the caption “Risk Factors” in our final prospectus filed with the Securities and Exchange Commission (“SEC”) on April 28, 2017 relating to our Registration Statement on Form F-1, and our other reports filed with the SEC , could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

    For further information, please contact:





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    Home Page, PhRMA, manufacturing pharmaceutical companies.#Manufacturing #pharmaceutical #companies

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    Key Account Manager – South West Products: Critical Care products, Infusion and Monitoring systems. Customers – Critical Care Depts, Nurses, Procurement Reporting to the National Sales Manager.

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    Clinical Nurse Educator

    Please Contact Alana

    UK – Open to location

    Clinical Nurse Educator Territory – North or South Products: Critical Care products, Infusion and Monitoring systems.

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    Major Account Manager

    Please Contact Alana

    UK National Accounts

    Major Account Manager Reporting to the UK Business Unit Head, ICU UK Medical, and the Major Account Manager is responsible for driving the business to penetrate and acquire major targeted accounts fo.

    Pharmaceutical it jobs

    Brand Manager – Oncology

    Office based – Surrey

    Title: Brand Manager Location: Surrey This role is office based although some travel can be expected within UK and abroad.

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    Clinical Support Specialist

    ROLE: Clinical Specialist PRODUCTS: Orthopaedics TERRITORY: CLIENT: Spinal Surgeons, Theatre Staff.

    Pharmaceutical it jobs

    Account Manager – Critical Care

    North- Manchester, Midlands, Yorkshire

    Pharmaceutical it jobs

    ROLE: Clinical Specialist (12month MAT cover) PRODUCTS: Orthopaedics TERRITORY: Midlands CLIENT: Surgeons, Theatre Staff.

    Pharmaceutical it jobs

    Technical Specialist Flow Cytometry

    Please contact Liam

    To act as the technical lead for Flow Cytometry products providing second line support and training to the field, and to in-house customer support staff. Key Responsibilities and Accountabilities.

    Pharmaceutical it jobs

    Senior Manager CLM Digital Marketing Specialist

    Pharmaceutical it jobs

    £24-35K OTE to £60K

    Recruitment Consultant / Account Manager Based High Wycombe The role is a blend of sales, service provision and administration in a highly competitive environment.

    Pharmaceutical it jobs

    Senior Account Manager

    Title : Senior Account Manager Reports to : Account Director or Client Services Director Role : To assist with the effective management of a variety of high quality scientific communications ensuri.

    Zenopa are currently undertaking 751 assignments and job searches. Of these 429 are not in the public domain. For details contact our specialist team.

    Pharmaceutical it jobs

    Executive

    Pharmaceutical it jobs





    Jobs and Careers, Baxter International, pharmaceutical biotech jobs.#Pharmaceutical #biotech #jobs

    A chance to impact lives

    Our employees around the world are connected by an enduring commitment to save and sustain lives. This higher purpose binds us as a company in doing work that matters. Start your search today to see how you can join us in our mission.

    Start your search now

    A career that matters

    Baxter employees are united in a mission to save and sustain lives. We are passionate about meeting the needs of the millions of people worldwide who depend on our medically necessary therapies and technologies, and about making a meaningful difference in our communities.

    Pharmaceutical biotech jobs

    Commercial Careers: Sales and Marketing Jobs

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    Students and Grads

    Our programs are more than a great introduction to Baxter’s environment and culture. Each day will give you a better working knowledge of your field and valuable insights into the healthcare industry. Students will gain hands-on experience with engaging projects, mentoring and other opportunities to make a valuable impact on the lives of our patients.

    Keep up with Baxter

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    Equal Employment Opportunity

    Baxter is an equal opportunity employer. Baxter evaluates qualified applicants without regard to race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, protected veteran status, disability/handicap status or any other legally protected characteristic.





    Group Sailing aboard the Schooner Woodwind in Annapolis, Maryland, middlebrook pharmaceuticals.#Middlebrook #pharmaceuticals

    Group Sailing

    Middlebrook pharmaceuticals

    We had a wonderful time aboard the Woodwind. Our family truly enjoyed the sail. We loved the fact that you used the guests to raise the sails, let us steer the boat and had so much interesting information regarding sailing and the sea. The crew was so friendly and made the day feel like we were out sailing with just old friends.

    We had such a great time! We had beautiful weather, calm seas, and lots of fun with the Captain and the entertainment. They both were so funny! Thanks again.

    Schooner Woodwind offers Group Sailing for groups of 18 people or more on a scheduled 2 hour public sail.

    If you are interested in exclusive use of the Woodwind please visit our Private Cruises page.

    Great Group Sail Ideas:

    • Staff Incentive
    • Client Appreciation
    • Vendor Gratitude
    • Team Bonding
    • Schmooze Cruises

    Why Book A Group Sail vs Public Tickets?

    • Group Sails can purchase tickets further in advance. Public Tickets can only be purchased six days prior to the date you want to sail.
    • Crew Gratuity is included on Group Sails.
    • Guarantee the sail will not be booked for a private event.
    • Discounted Base Ticket Price

    Group Sailing Rates

    Middlebrook pharmaceuticals

    (Ticket + Gratuity + Tax)

    (Ticket + Gratuity + Tax)

    (Ticket + Gratuity + Tax)

    (Ticket + Gratuity + Tax

    (Ticket + Gratuity + Tax)

    (Ticket + Gratuity + Tax)

    All prices include a soft drink, snack, taxes and 18% gratuity.

    Group Sailing Schedule

    Middlebrook pharmaceuticals

    Italicized Times can only be booked by a Group Sail.

    April 15 28

    Tuesday Sunday

    April 29 May 12

    Tuesday Sunday

    5:30 pm 7:30 pm (Sunset Sail*)

    * Monday Thursday we have different activities on our Sunset Sails- Check out our Schedule here.

    May 13 August 27

    Seven Days a Week

    6:30 pm 8:30 pm (Sunset Sail*)

    * Monday Thursday we have different activities on our Sunset Sails- Check out our Schedule here.

    August 28 October 1

    Seven Days a Week

    5:30 pm 7:30 pm (Sunset Sail*)

    * Monday Thursday we have different activities on our Sunset Sails- Check out our Schedule here.

    October 2- 17

    Only Sailing for Private Events Only

    October 18 29

    Tuesday Sunday

    Italicized Times can only be booked by a Group Sail.

    Middlebrook pharmaceuticals

    Payment Schedule:

    $300 deposit is due at time of booking to hold the date and the customer must sign an agreement to buy a minimum of 18 tickets. Final Head Count Balance are due 2 weeks prior to the cruise date. All remaining spaces will be opened to the public six days prior to the date of the sail. Boarding passes can be picked up at the dock office on the day of your cruise.

    Cancellations:

    Our cruises do not allow for any cancellations. Our weather policy: if the weather is stormy and the Captain feels it is not safe to depart, then all monies are refunded, excluding any catering ordered. All attempts will be made to reschedule the cruise if possible.

    If it is raining we will still sail!!

    We do offer complimentary rain ponchos.





    PHARMACY PRESCRIPTION PACKAGING SUPPLIES, pharmacy company.#Pharmacy #company

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    PURVEYORS OF PHARMACY PRESCRIPTION PACKAGING SUPPLIES

    . WE’RE THAT ONE STEP BEYOND ordinary!

    Telephone (800) 373-7162 Fax (800) 373-7163

    LASER PRESCRIPTION LABELS AS LOW AS $20.20 PER THOUSAND!

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    Any questions? You may e-mail us by clicking on the envelope below.

    Pharmacy company

    Stay Tuned! More later.

    This page was last updated: 09/07/2012 06:50:20 PM





    Middlebrook pharmaceuticals, middlebrook pharmaceuticals.#Middlebrook #pharmaceuticals

    Amoxicillin

    A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation.

    Middlebrook pharmaceuticals

    Structure for DB01060 (Amoxicillin)

    Middlebrook pharmaceuticals

    Middlebrook pharmaceuticalsMiddlebrook pharmaceuticalsMiddlebrook pharmaceuticalsMiddlebrook pharmaceuticals

    Middlebrook pharmaceuticals

    Middlebrook pharmaceuticals

    Middlebrook pharmaceuticals

    Monoisotopic: 365.104541423 Chemical Formula C16H19N3O5S InChI Key LSQZJLSUYDQPKJ-NJBDSQKTSA-N InChI

    Pharmacology

    For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).

    Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by -lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of -lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a -lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through -lactamase production.

    Mechanism of action

    Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.

    Rapidly absorbed after oral administration.

    Volume of distribution Not Available Protein binding

    In blood serum, amoxicillin is approximately 20% protein-bound

    Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins

    Route of elimination

    Most of the amoxicillin is excreted unchanged in the urine; its excretion can be delayed by concurrent administration of probenecid.

    Clearance Not Available Toxicity

    Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.

    Affected organisms

    • Enteric bacteria and other eubacteria
    • Gram negative and gram positive bacteria
    • Streptococcus pyogenes
    • Streptococcus pneumoniae
    • Borrelia burgdorferi
    • Chlamydia pneumoniae
    • Salmonella typhi
    • Chlamydia psittaci

    Pathways Not Available Pharmacogenomic Effects/ADRs Browse all” title=”About SNP Mediated Effects/ADRs” id=”snp-actions-info” class=”drug-info-popup” href=”javascript:void(0);”> Not Available





    AstraZeneca Bulk Pharmaceutical – Pharmaceutical Technology, pharmaceutical magazine.#Pharmaceutical #magazine

    AstraZeneca Bulk Pharmaceutical

    Project Type

    Estimated Investment

    Sponsor Financing

    Tablets

    Pharmaceutical magazine

    AstraZeneca’s facility in Guayama, Puerto Rico.

    Pharmaceutical magazine

    PRIDCO hopes that Zeneca’s investments will enhance the island’s reputation as a manufacturing centre.

    Pharmaceutical magazine

    According to the company’s own figures, its soluble, oral version of Zomig was widely welcomed by the sample group. If this is the case, it should boost demand.

    In July 1997, AstraZeneca announced plans to invest 15m in its Guayama facility in Puerto Rico. The money was invested in a new bulk pharmaceutical purification plant to supply the global market with zolmitriptan, the active ingredient in a new treatment for migraine called Zomig. The go-ahead for the construction of the plant, which is managed by Zeneca s wholly owned subsidiary, IPR Pharmaceuticals Inc., confirmed the company s decision to increase its investment in the island.

    Detailed design plans for the Guayama purification plant were completed by June 1997 and construction began in early 1998. Since then, FDA accreditation has been obtained and the plant now supplies to market. IPR, the established engineering contractors who have design, engineering, procurement, construction management and commissioning / validation experience in Puerto Rico have completed the project. The new facility went operational at the end of 2000. In 2005, the plant was sold off as part of AstraZeneca s restructuring activities.

    Guayama bulk purification plant

    The Guayama bulk purification plant is located adjacent to an existing purification facility. The plant has several times the capacity for peak demands of Zomig. Consequently, spare capacity is available for other products, as required. Bulk zolmitriptan requirements for all markets are sourced from this plant, while tableting and packaging is undertaken at other sites.

    After acquiring zolmitriptan in September 1996 (now sold under the trade name Zomig ), AstraZeneca launched tableting facilities for the drug at IPR s Carolina plant in Puerto Rico. However, as demand for Zomig had been growing (according to company research), it was thought that greater manufacturing capabilities were needed to meet the pharmaceutical industry s requirements. As one of the drug s sole manufacturers, the bulk purification plant at Guayama has made a significant impact.

    Astrazeneca investment plan

    The Guayama project was part of AstraZeneca s large-scale investment project in Puerto Rico. In addition to the upgrade of the company s facilities at Guayama, AstraZeneca has also upgraded its existing plant at Can vanas. The plant was expanded and inaugurated in March 2004, with a total investment of 400m.

    The 134,000ft plant used to produce Crestor, a cholesterol drug, and Casodex, a medication for treating prostate cancer. It had an annual capacity of up to seven billion tablets. The plant also took care of the packaging and distribution activities of AstraZeneca and other products developed by the company in Puerto Rico.

    IPR Pharmaceuticals bought the Can vanas facility in 1998 from Chiron Corporation. IPR Pharmaceuticals invested more than $650m in both the Can vanas and its Carolina facility.

    Puerto Rico pharmaceutical market

    The pharmaceutical industry in Puerto Rico is huge. According to the 1997 manufacturing census of the Department of Labour and Human Resources, some 22,000 people work at 79 different pharmaceutical plants.

    The joint decision by IPR and the Puerto Rico Industrial Development Company (PRIDCO) to set the upgrade project at Guayama in motion was testament to the confidence in this sector.

    The new plant has enhanced the island s reputation as a world-class manufacturing centre that is home to the most important and prominent international pharmaceutical companies.

    Other life-science companies have also invested in projects in Puerto Rico, including Pharmacia Upjohn ($100m), Ocular Sciences / American Hydron ($25m) and Thermometric ($700,000).

    IPR Pharmaceuticals Puerto Rico operations

    IPR Pharmaceuticals first plant in Puerto Rico was launched in Carolina in 1986. The plant develops several drugs, including Accolate, a medication for asthma, beta-blockers Tenormin and Tenoretic, Zestril, and ACE inhibitors and migraine treatments, Zestoretic and Zomig.

    AstraZeneca manufactures several top-selling drugs and a range of high-potential therapies. Its product portfolio includes Casodex, Arimidex, Faslodex and Iressa for treating cancer; Nexium for gastrointestinal diseases; Symbicort for asthma treatment; Atacand for hypertension and Seroquel for the treatment of schizophrenia.





    Elder Pharma MD passes away, shadow over company intensifies, Business Line, elder pharmaceuticals.#Elder #pharmaceuticals

    Elder Pharma MD passes away, shadow over company intensifies

    Elder pharmaceuticals

    Elder pharmaceuticals

    Drugmaker Elder Pharmaceuticals Managing Director and Chief Executive Officer Alok Saxena has passed away plunging the debt-ridden drugmaker into greater uncertainity.

    Alok (52) was the elder son of Elder founder late Jagdish Saxena who passed away in October 2013. But over the last three odd years, the company has been mired in multiple controversies from a family feud to defaulted fixed deposit payments to investors and depositors, delayed wages to workers, allegations of bribery against company top-brass and wind-up petitions in the Courts against the company.

    Alok s younger brother and Elder Pharma s Chief Operating Officer Anuj Saxena is also an actor, having played lead roles in Hindi television serials. He also heads Elder Health Care. In fact, Elder Pharma s annual report 2013, last available on the Bombay Stock Exchange, records the shelving of plans to merge Elder Health Care with Elder Pharma.

    Brand sale to Torrent

    Not too long ago, Elder Pharma was a thriving company on the Indian pharmaceutical landscape with popular brands like Shelcal and Tiger Balm (which it imported and sold in India) in its kitty. But in December 2013, Elder inked a 2,004-crore deal to sell its branded drugs business in India and Nepal to Torrent Pharmaceuticals. The deal was expected to bail out Elder Pharma then saddled with a 1,300-crore debt.

    Crossing over as part of the deal was Shelcal, then estimated to be a 170-crore brand, besides 30 others in segments including women s healthcare, pain management, wound-care and nutraceuticals. Elder s management then said that they were left with 25 in-licensing deals and its exports business.

    Elder tried to salvage its reputation by planning for life beyond the Torrent acquisition of its brands. The company had businesses in the United Kingdom, Ghana and Bulgaria, from acquisitions in these countries.

    But in October 2015, Elder Pharma said it would repay its creditors and investors by raising funds through a combination of debt, equity and asset sale. And that included the sale of its stake in its subsidiaries in the UK and Bulgaria.

    Elder Pharma has long been plagued with speculation of being up for sale, factories, assets and all. It s published total income stands at Rs 25 crore, upto March 2015 with a net loss of 51 crore.

    With the passing of Elder scion Alok Saxena, the future of the remaining employees with the troubled drugmaker plunges further into uncertainty, said a company insider.





    Medzilla; Biotech Jobs, Pharmaceutical Jobs, Pharmaceutical Sales Jobs, Resumes, Medical Career, Job Board, Biopharmaceutical Jobs,

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    Working to spread awareness and education about the importance of secure drug disposal.





    EGRX stock quote – Eagle Pharmaceuticals, Inc, eagle pharmaceuticals inc.#Eagle #pharmaceuticals #inc

    Eagle Pharmaceuticals, Inc. Common Stock Quote & Summary Data

    Stock Details
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    Intraday Chart

    Company Description (as filed with the SEC)

    Eagle Pharmaceuticals, Inc. is a specialty pharmaceutical company registered at and with principal offices at 50 Tice Boulevard, Suite 315, Woodcliff Lake, New Jersey 07677. On November 16, 2016, we purchased all of the outstanding capital stock of Arsia Therapeutics, Inc. (“Arsia”), and subsequently changed its name to Eagle Biologics, Inc. (“Eagle Biologics”). Business Our business model is to develop proprietary innovations to FDA-approved, injectable drugs, that offer commercial and/or functional advantages to currently available alternatives. We have historically been, and will continue to primarily be, focused on developing and commercializing injectable drugs, primarily in the critical care and oncology areas, using the United States Food and Drug Administration (“FDA”)’s 505(b)(2) New Drug Application (“NDA”) regulatory pathway. . More .

    Risk Grade

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    Eagle pharmaceuticals inc





    Elder Pharma MD passes away, shadow over company intensifies, Business Line, elder pharmaceuticals.#Elder #pharmaceuticals

    Elder Pharma MD passes away, shadow over company intensifies

    Elder pharmaceuticals

    Elder pharmaceuticals

    Drugmaker Elder Pharmaceuticals Managing Director and Chief Executive Officer Alok Saxena has passed away plunging the debt-ridden drugmaker into greater uncertainity.

    Alok (52) was the elder son of Elder founder late Jagdish Saxena who passed away in October 2013. But over the last three odd years, the company has been mired in multiple controversies from a family feud to defaulted fixed deposit payments to investors and depositors, delayed wages to workers, allegations of bribery against company top-brass and wind-up petitions in the Courts against the company.

    Alok s younger brother and Elder Pharma s Chief Operating Officer Anuj Saxena is also an actor, having played lead roles in Hindi television serials. He also heads Elder Health Care. In fact, Elder Pharma s annual report 2013, last available on the Bombay Stock Exchange, records the shelving of plans to merge Elder Health Care with Elder Pharma.

    Brand sale to Torrent

    Not too long ago, Elder Pharma was a thriving company on the Indian pharmaceutical landscape with popular brands like Shelcal and Tiger Balm (which it imported and sold in India) in its kitty. But in December 2013, Elder inked a 2,004-crore deal to sell its branded drugs business in India and Nepal to Torrent Pharmaceuticals. The deal was expected to bail out Elder Pharma then saddled with a 1,300-crore debt.

    Crossing over as part of the deal was Shelcal, then estimated to be a 170-crore brand, besides 30 others in segments including women s healthcare, pain management, wound-care and nutraceuticals. Elder s management then said that they were left with 25 in-licensing deals and its exports business.

    Elder tried to salvage its reputation by planning for life beyond the Torrent acquisition of its brands. The company had businesses in the United Kingdom, Ghana and Bulgaria, from acquisitions in these countries.

    But in October 2015, Elder Pharma said it would repay its creditors and investors by raising funds through a combination of debt, equity and asset sale. And that included the sale of its stake in its subsidiaries in the UK and Bulgaria.

    Elder Pharma has long been plagued with speculation of being up for sale, factories, assets and all. It s published total income stands at Rs 25 crore, upto March 2015 with a net loss of 51 crore.

    With the passing of Elder scion Alok Saxena, the future of the remaining employees with the troubled drugmaker plunges further into uncertainty, said a company insider.





    ElderServe Health, elder pharmaceuticals.#Elder #pharmaceuticals

    Elder pharmaceuticals

    For more information or to schedule a visit from our staff contact us today:

    Toll free: 1-800-370-3600 | TTY/TDD: 711

    Elder pharmaceuticals

    ElderServe Health now RiverSpring at Home is a New York State Managed Long Term Care Program that is designed to help you remain in your own home and live as independently as possible.

    Working with your physician, we provide you with high quality, comprehensive services tailored specifically to your needs.

    We monitor your medical and social needs, and, as your condition may change, we are there to make any changes needed in your plan of care – at any time, day or night.

    View Our Calendar

    View Our Newsletter

    MEMBER ADVISORY COMMITTEE MEETINGS:

  • March 29, 2017
  • June 1, 2017
  • September 8, 2017
  • December 6, 2017

    For more information or to schedule a visit from our staff, call toll free:

    Our Provider Network:

    Elder pharmaceuticals

    Services

    ElderServe Health now RiverSpring at Home provides access to care 24 hours a day, 7 days a week, 365 days a year. You can access services by calling the Member Services Department at 1-800-370-3600.

    Depending on your needs, ElderServe Health now RiverSpring at Home provides:

    • Care Coordination
    • Nurse services, in connection with home health care
    • Therapies, including physical, occupational and speech at your home and in other settings
    • Social Work Services
    • Personal Care
    • Nutritional Counseling
    • Respiratory Therapy
    • Durable Medical Equipment
    • Medical and Surgical Supplies
    • Prosthetics, Orthotics and Orthopedic Footwear
    • Enternal and Parenteral Supplements
    • Telehealth Delivered Services
    • Personal Emergency Response System
    • Non-Emergency Health-related Transportation
    • Adult Day Health Care
    • Social Day Care
    • Podiatry (Foot Care)
    • Hearing Exams and Hearing Aids/Batteries
    • Dentistry
    • Eye Exams and Eyeglasses
    • Home-delivered and Congregate Meals
    • Social and Environmental Supports
    • Nursing Home Care (Institutional Medicaid required)
    • Consumer Directed Personal Assitance Services
    • Ongoing Health Education

    Eligibility

    You may be eligible to join ElderServe Health now Riverspring at Home if you:

    • Are 18 years old or older
    • Live in New York City (The Bronx, Manhattan, Queens, Brooklyn, Staten Island), Westchester, Nassau or Suffolk counties.
    • Are Medicaid eligible
    • Are eligible for nursing home level of care
    • Are approved by the Conflict Free Evaluation & Enrollment Center
    • Require care management and the long term services of ElderServe Health now RiverSpring at Home for at least 120 days from the date of enrollment

    Your Health is our Concern

    Your ElderServe Health now RiverSpring at Home nurse and trained home care staff will visit you at home, as necessary, to provide assistance with services such as meal preparation, personal care, shopping, social work services or even modifications to your home to enable you to function better.

    Non-Covered Services: among services that are not covered by ElderServe Health now RiverSpring at Home are physician services, hospital services, emergency transportation, and pharmaceuticals (full list is available). These non-covered services are paid by Medicare and/or Medicaid separately, and you may use any provider you choose for non-covered services.

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